Moreover, Zuo et al. predicted and validated the downregulation of both circRNAs in lung adenocarcinoma, implicating them in pathogenesis through the circ_0004789/miR-877–5p/C1orf115 and circ_0043256/miR-4496/PRICKLE2 axes [47]. Here, C1orf115 is linked to lung adenocarcinoma.