CHI3L1 and sarcopenia: A study of 136 male HCC patients undergoing liver transplantation revealed that skeletal-muscle-derived chitinase-3-like protein 1 (CHI3L1) and its soluble receptor sTNF-R1 are markedly elevated and closely linked to lipid-metabolic derangement, identifying them as key molecules associated with sarcopenia and predicting HCC recurrence (Lu et al., 2022).