The gene expression patterns of NAFLD and sarcopenia exhibit a significant positive correlation. We identified four pairs of genes that are co-up-regulated or co-down-regulated: HIF1A, ATG5, ADM, and CST3 are highly expressed in both diseases, whereas BMP2, BMPR2, TFDP1, and E2F6 are expressed at low levels. This evidence concerns the gene E2F6 and metabolic dysfunction-associated steatotic liver disease.