Median ACTH hormone concentrations were higher in LC compared with APC group (25 pg/mL [IQR 16.1] vs 13 pg/mL [IQR 13.2]; p = 0.003), while remaining within normal laboratory reference ranges (Figures 5A, B). Thirty-two patients (26 with LC [21.6% of all LC patients] and 6 APC [46% of all APC patients]) met the inclusion criteria for the ACTH-test; five declined participation. Here, POMC is linked to laryngotracheoesophageal cleft.