POMC and laryngotracheoesophageal cleft: Similarly, a preliminary report presented at CROI 2025 (abstract only, not peer-reviewed) on SC in LC, described a trend toward elevated ACTH levels (p = 0.06) and lower morning SC (p = 0.11) in LC patients comparing to APC, although the study lacked a healthy control group and stratification by LC severity (Annukka Antar et al., 2025).