CASP8 and schizophrenia: We found that transcripts encoding factors downstream of TNFRs were increased in high-inflammation schizophrenia, including BCL2, MCL1, CASP7, and P53 mRNAs, while BAX, BID, CASP1, CASP3, CASP8, and CASP9 mRNAs seemed to be unchanged by diagnosis alone.