Zhou et al. (2021) demonstrated that nuclear translocation of GDF15 modulates cancer-related genes, including KiSS-1, through Sp1-dependent promoter activation, ultimately inhibiting cell proliferation and invasion. Similarly, Mueller et al. (2011) showed that nuclear KiSS-1 can act as a transcriptional co-regulator involved in tumor suppression. Here, SP1 is linked to cancer.