APOB and heart failure: The Apo B/A1 ratio proved to be a superior marker for ASCVD stratification compared to Apo A1 or Apo B alone.38 For instance, Apo B levels did not differ significantly when patients suffering from stroke and heart failure were compared with the control group (Online Supplementary Table 10), whereas the Apo B/A1 ratio showed statistically significant differences across all ASCVD subclasses when each subclass is compared with the control group (Online Supplementary Table 11).