Apolipoprotein A1, the major protein component of HDL, is integral to the process of reverse cholesterol transport,9,10 exerting anti-inflammatory and antioxidant effects that confer protection against ASCVD.11,12 In contrast, elevated levels of Apo B, which is found predominantly on low-density lipoprotein particles, are associated strongly with increased ASCVD risk,13,14 reflecting the proatherogenic properties of low-density lipoprotein cholesterol (LDLC).15 The gene discussed is APOB; the disease is atherosclerosis.