Other inflammatory mediators and cytokines involved in the development of RA include interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-10 (IL-10), granulocyte-macrophage colony-stimulating factor (GM-CSF), growth hormone, interferon (IFN), and fibroblast growth factor-2 (FGF-2) [13]. Here, IL10 is linked to rheumatoid arthritis.