For instance, a Hungarian real-world study of 82 HER2-positive patients identified Ki-67 >60% as predictive of higher pCR rates [19], while Resende et al. in a cohort of 310 patients with early HER2-positive breast cancer found Ki-67 ≥50% to be a significant predictor [20]. This evidence concerns the gene MKI67 and breast carcinoma.