Within the Amyloid, Tau and Neurodegeneration research framework, hypometabolism follows the accumulation of amyloid-β (Aβ) plaques and tau tangles and precedes neuronal loss.1 The presence of Aβ is believed to promote tau spread from the medial temporal lobe to neocortical regions.13 Widespread tau then becomes closely linked to neurodegeneration, resulting in cognitive decline.14 However, the spatio-temporal interplay between Aβ, tau and hypometabolism in the disease progression is unclear. Here, MAPT is linked to Mental deterioration.