MAPT and Alzheimer disease: Though FDG-PET and FTP-PET are typically assumed to overlap and predict neuronal loss,1 our findings suggest a lack of local specificity between hypometabolism and tau accumulation in temporo-parietal brain regions, which is in agreement with the regional discrepancy between early tau deposition in the medial temporal lobe52,60 and early hypometabolism in the precuneus and posterior cingulate in AD.