PSEN1 and memory impairment: Across the AD continuum, hypometabolism in the temporal lobe and posterior cingulate is associated with memory impairment, visuospatial and language deficits as well as global cognitive dysfunction.6,29,31,32,35,68 In our study, we also observed that lower glucose metabolism in the hippocampus, inferior temporal and entorhinal was associated with worse memory performance in PSEN1 mutation carriers.