FKBP5 and major depressive disorder: Interestingly, in previous work, deletion of Fkbp5 in mice did not change anxiety-related, stress-coping, or depression-like behavior under basal conditions, but led to more active-coping behavior following acute stressors (Touma et al., 2011), including the forced swim test (Hartmann et al., 2012; Hoeijmakers et al., 2014).