These TCRs target epitopes of diverse T1D-associated autoantigens, including GAD65, G6PC2(also known as IGRP, Islet-specific Glucose-6-phosphatase catalytic subunit-Related Protein), Preproinsulin (PPI), Proinsulin or insulin (166) and a growing repertoire of TCRs specific for Hybrid Insulin Peptides (HIPs) (167, 168). The gene discussed is INS; the disease is type 1 diabetes mellitus.