TFRC and malignant colon neoplasm: To verify the specific targeting as well as killing effect of AIE@HFn-scfv on gastric cancer tumor cells, we selected tumor cell lines and normal cell lines with different expressions of Claudin18.2 and CD71 molecules (Fig. 3A), including cervical cancer Hela cells, colon cancer MC-38 cells, human-derived normal L02 liver cells, gastric cancer MGC803 cells, human embryonic kidney cells HEK293, HEK293 cells with low expression of Claudin18.2 (HEK293-1), and HEK293 cells with high expression of Claudin18.2 (HEK293-2).