PDZK1IP1 and systemic sclerosis: The TAPSE/sPAP ratio trended toward an inverse association with SSc (OR 0.31, 95% CI 0.08–1.23, p = 0.096), whereas age was not independently associated with SSc in this model (OR 1.02/year, 95% CI 0.98–1.07, p = 0.34) (Table 6).