Mutations in APC, CSF1R, EGFR, ERBB4, FGFR3, FLT3, HRAS, KDR, MET, NPM1, PDGFRA, PIK3CA, RET, SMAD4 and STK11 were detected in HCC patients across all etiologies. The gene discussed is PIK3CA; the disease is hepatocellular carcinoma.