Mutations in APC, CSF1R, EGFR, ERBB4, FGFR3, FLT3, HRAS, KDR, MET, NPM1, PDGFRA, PIK3CA, RET, SMAD4 and STK11 were detected in HCC patients across all etiologies. Here, PDGFRA is linked to hepatocellular carcinoma.