OMA1, a mitochondrial inner membrane zinc metalloprotease, is involved in the proteolysis of OPA1 when mitochondria are stressed, (Ehses et al., 2009), and glomerular OMA1 Zinc Metallopeptidase (OMA1) was activated in a time-dependent manner in DKD (Q et al., 2022). Here, OPA1 is linked to diabetic kidney disease.