In vitro experiments on HK2 cells, phosphoglycerate mutase family member 5 (PGAM5) exacerbates diabetic renal tubular injury, while AMPK activators mitigate DKD by rescuing the dephosphorylation of DRP1S637 and inhibiting the mitochondria-translocation of DRP1, that is to reduce mitochondrial fission through the AMPK/SP1/PGAM5 pathway (Liu et al., 2020). Here, PGAM5 is linked to diabetic kidney disease.