Recent research has indicated that FGFR1 mutations are linked to spontaneous hemorrhage in pediatric low-grade gliomas (Ishi et al., 2021), although the exact mechanism remains unclear and may be driven by FGFR1’s direct effects rather than the MAPK pathway (Karthigeyan et al., 2019; Linscott et al., 2008). The gene discussed is FGFR1; the disease is central nervous system cancer.