The typical pathological features of AD include the deposition of amyloid β (Aβ) plaques in the brain, which form extracellular deposits, neurofibrillary tangles (NFTs) resulting from the hyperphosphorylation of tau protein within neurons, as well as neuronal apoptosis and synaptic loss caused by increased inflammation and oxidative stress (4). The gene discussed is MAPT; the disease is Alzheimer disease.