NFKB1 and experimental autoimmune encephalomyelitis: In immune cells, it plays a key role in activating NF-κB in response to antigen stimulation, while in neuronal cells, it is involved in neuroinflammation, especially in diseases like experimental autoimmune encephalomyelitis (EAE), where it contributes to pathogenic Th17 cell function via non-degradative polyubiquitination (46).