LRRK2 and Alzheimer disease: Leucine-rich repeat kinase 2 (LRRK2) mediated phosphorylation of Rab12 and Rab10 contributes to endolysosomal dysfunction in AD, with pS106-Rab12 accumulation in GVBs and co-pathology with tau, suggesting a key role for LRRK2 in tau-related neurodegeneration (31).