Since another study found that dermal fibroblast cultures acquired from a POAG patient with the E50K mutation expressed lower levels of OPTN in comparison to normal patients (Rezaie et al., 2002), the idea that it may be the reduced expression of OPTN and therefore increased activation of TNFα stimulated NF-κB that leads to NTG was supported (Zhu et al., 2007). The gene discussed is OPTN; the disease is open-angle glaucoma.