As a result, research has been focused on understanding contributions of TBK1 to various human diseases, such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), NTG, childhood herpes encephalitis (HSE), autoimmune diseases, cancer, and viral infections (Morton et al., 2008; Kawase et al., 2012; Ritch et al., 2014; Freischmidt et al., 2015; Ahmad et al., 2016; Meena et al., 2016; Oakes et al., 2017; Ruyuan et al., 2020; Medchalmi et al., 2021; Runde et al., 2022). Here, TBK1 is linked to frontotemporal dementia.