Notably, HOTAIR exhibits pan-pathological regulatory capacities, driving oncogenic phenotypes in epithelial malignancies (including esophageal/gastric/colorectal carcinomas), modulating vascular calcification in cardiovascular pathologies, governing cartilage homeostasis in degenerative joint diseases, and rewiring placental signaling cascades in hypertensive gestational disorders—predominantly via Wnt/β-catenin-dependent mechanisms [42–48]. The gene discussed is HOTAIR; the disease is osteoarthritis.