INS and Insulin resistance: According to the mechanisms mentioned above, the LCHF-KD could mitigate ER stress-related insulin resistance by inhibiting lipotoxicity (92), increasing insulin sensitivity with concordant prevention of insulin resistance (21), having anti-inflammatory Effects (94), the antioxidant effect (96), improving hormonal balance (98), augmenting autophagy (86), and modulating the gut microbiota population (97).