In summary, strategies for regulating mitochondrial dynamics in CRC focus on key molecular nodes: IDH1 acetylation (a driver of fission), the chromodomain helicase DNA-binding protein 6 (CHD6)-transmembrane protein 65 (TMEM65) axis (fusion maintenance), zinc finger protein 746 (ZNF746, fusion inhibition), and human α-lactalbumin Made Lethal to Tumor cells (HAMLET, respiratory reprogramming). The gene discussed is IDH1; the disease is colorectal carcinoma.