CD133+/CD44+ CRC stem cells overexpress Bcl-2/adenovirus E1B 19 kDa-interacting protein 3-like (BNIP3L), which clears doxorubicin-induced damaged mitochondria through enhanced selective autophagy, thereby maintaining low mitochondrial superoxide levels and significantly reducing chemotherapy sensitivity.96 Here, CD44 is linked to colorectal carcinoma.