In epithelial and neuroendocrine tumors, TrkB promotes survival, invasion and resistance to detachment stress (anoikis) via ERK, PI3K–AKT and PLCγ; these conserved signaling solutions are detectable in OS models and likely contribute to adaptation within the hypoxic, stiff bone niche (36–38). Here, NTRK2 is linked to neuroendocrine neoplasm.