Human cerebral endothelial cell-derived exosomes carrying elevated miR-214 (hCEC-Exo-214) have been demonstrated to reduce the levels of P-glycoprotein (P-gp) and splicing factor 3B subunit 3 (SF3B3) in HCC when combined with oxaliplatin and sorafenib. Here, SF3B3 is linked to hepatocellular carcinoma.