(34) found that macrophages that overexpressing recombination signal binding protein for immunoglobulin kappa J region (RBPJ) secreted exosomal circRNAs, which inhibited the proliferation and metastasis of HCC and promoted apoptosis via the hsa_circ_0004658/miR-499b-5p/JAM3 pathway. Here, JAM3 is linked to hepatocellular carcinoma.