Strikingly, recipients of Fn-DCs exhibited aggravated colitis compared to mice receiving untreated DCs or PBS, with accelerated body weight loss (Figure 4B), colon shortening (Figures 4D, E), elevated DAI scores (Figure 4C), and more severe histological damage, including transmural ulceration, crypt abscess formation, and inflammatory infiltration (Figures 4F, G). The gene discussed is FN1; the disease is colitis.