Notably, we found that AMs from tumor-bearing lungs exhibited increased expression of genes related to citrate synthesis and transport (Cs and Slc25a1, respectively), cytoplasmic conversion of citrate to acetyl-CoA (Acly), and acetate conversion to acetyl-CoA (Acss1/2) in addition to traditional glycolytic genes such as glucose transporters (Slc2a1), mitochondrial pyruvate carriers (Mpc1), and hypoxia-inducible factors (Hif1a) (Figure 2E). Here, HIF1A is linked to neoplasm.