IGHE and anaphylaxis: In a subsequent study, the authors revealed the significant role of glycosylated IgE-ICs in triggering an increased anti-IgE IgG response and a higher production of IgG-secreting plasma cells compared to the deglycosylated IgE-ICs, which showed a marked decrease in IgE clearance and protection of systemic anaphylaxis, indicating that the IgE glycans themselves are the main contributors to the protective effect induced by the IgE-ICs and could further mediate a strong anti-IgE IgG response and control of serum IgE levels (130).