Pathogenic IgE has been implicated in rheumatoid arthritis (RA) (260, 261), bullous pemphigoid (BP) (262), atopic dermatitis (AD) (263), systemic lupus erythematosus (SLE) (264), uveitis (265), systemic sclerosis (266), multiple sclerosis (267), Hashimoto thyroiditis, and Graves disease (268, 269), and chronic spontaneous and inducible urticaria (270, 271). The gene discussed is IGHE; the disease is urticaria.