We obtained eight genes ARF Like GTPase 6 Interacting Protein 4 (ARL6IP4), ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 (ATP2A1), crystallin alpha B (CRYAB), extracellular leucine rich repeat and fibronectin type III domain containing 2 (ELFN2), microtubule associated protein 2 (MAP2), methionine adenosyltransferase 1A (MAT1A), origin recognition complex subunit 1 (ORC1), and POU class 4 homeobox 1 (POU4F1) which have influence on the OS of CRC patients to build a prognostic signature. The gene discussed is CRYAB; the disease is colorectal carcinoma.