In lipopolysaccharide (LPS)-induced sepsis models among animals, exogenous administration of LPA or LPA receptor agonism suppresses the release of proinflammatory factors, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and monocyte chemoattractant protein-1 (MCP-1). This evidence concerns the gene TNF and Sepsis.