Interestingly, the researchers discovered that the n-3 polyunsaturated fatty acid docosahexaenoic acid (22:6n-3; DHA), an active derivative of fish oil, dose-dependently downregulated GZMB in human pancreatic cancer PT45 cells and human bladder cancer RT112 cells. The gene discussed is GZMB; the disease is familial pancreatic carcinoma.