Recently, Zhu JQ and colleagues analyzed single-cell sequencing data from intrahepatic cholangiocarcinoma (iCCA) in the GEO database and found that tumor tissues exhibited a higher percentage of GZMB+ B cells, which are chemotactically recruited by tumor cells via the MIF-(CD74+CXCR4) signaling pathway. The gene discussed is CXCR4; the disease is neoplasm.