As shown in the enriched chord diagram, the hub genes Tnf, Il1b, Il6, and Nfkb1 were downregulated while Sdhb, Uqcrc2, Ndufb8, and Tfam were upregulated related to the AGE‐RAGE signaling pathway, oxidative phosphorylation, IL‐17 signaling pathway, pathways of neurodegeneration—multiple diseases, chemical carcinogenesis—reactive oxygen species, MAPK signaling pathway, huntington disease, and parkinson disease (Figure 5C; Tables S8 and S9). This evidence concerns the gene RENBP and juvenile Huntington disease.