This analysis identified a compact 12‐gene module with significant network connectivity and a clear functional polarity‐anti‐inflammatory (TNF/IL‐1β/IL‐6/NF‐κB↓) and pro‐mitochondrial (TFAM/OXPHOS subunits↑)‐that mechanistically accords with the improved muscle function observed after PSE treatment in the combined Dex + HFHS atrophy model. Here, IL1B is linked to Atrophy.