ADAMTS13 and thrombotic thrombocytopenic purpura: ADAMTS-13 (a disintegrin and metalloprotease with thrombospondin type 1 motifs, member 13), a metalloprotease involved in the pathophysiology of TTP, is a multidomain glycoprotein (M, D, T, C, S, T2T8, and CUB1-CUB2 domains) circulating in a latent, closed conformation, maintained by self-interaction between its spacer (S) and CUB domains.