PHACTR1 and hypertensive disorder: ,11 Genetic studies of genes associated with other arteriopathies have not identified a clear overlap with FMD, but a recent genome-wide association study revealed a single nucleotide polymorphism (rs9349379-A) in the PHACTR1 locus, which confers an estimated 1.4-fold increased risk of developing FMD.12, 13, 14 This variant has also been associated with cervical artery dissection, hypertension, and migraine, which are commonly seen FMD-associated abnormalities.3