PPARGC1A and neuropathy: This study is the first to systematically investigate the role of PACAP in PTX‐induced PIPN in mice and reveals a new mechanism by which PACAP alleviates oxidative stress and mitochondrial damage in DRG of PIPN mice by upregulating PGC‐1α and HO‐1 proteins, thereby relieving chemotherapy‐induced neuropathy.