Age ≥ 40, HF NYHA II–IV, HFpEF (LVEF ≥ 50%), BMI ≥ 30 kg/m2, 6MWD 100–425 m, KCCQ‐CSS ≤ 80Objective HF evidence (elevated NT‐proBNP, LA enlargement, or elevated filling pressures)Enrichment if recent HF decompensation or eGFR < 70. This evidence concerns the gene NPPB and hydrops fetalis.