Heat-clearing and turbidity-purging Chinese medicines directly target the superficial symptom of damp-heat toxin pathogen via activating the AMPK/PPARα/PGC-1α axis, upregulating key fatty acid oxidation enzymes such as CPT1A, downregulating lipogenic factors including ACC and FAS, correcting lipid metabolism disorders, blocking the TGF-β1-Smad2/3 fibrotic pathway, and inhibiting lipotoxicity-mediated EMT. The gene discussed is SMAD2; the disease is Disorder of lipid metabolism.