Using a clinically relevant murine AKI model, we point out that STIM1- and ORAI1-deficiency in neutrophils prevents neutrophil recruitment into the kidney during sterile inflammation.<h4>Conclusion</h4>Thus, we uncover stimulus specific integrin regulation in neutrophils as a critical determinant of an adequate immune response and pinpoint the clinical relevance of STIM1 and ORAI1. Here, ORAI1 is linked to acute kidney injury.