Notably, NKG2D-ADCC induced robust NK cell-mediated lysis of ovarian cancer cells in both short- and long-term cytotoxicity assays.Together, these findings demonstrate that the NKG2D-ADCC fusion protein potently enhances NK cell responses against ovarian cancer cells, supporting its promise as a novel immunotherapeutic strategy. Here, KLRK1 is linked to ovarian cancer.