Patients were followed up over 2 years duration for assessment of treatment response.<h4>Results</h4>At cutoff levels 11.54 and 11.39 MAGE-A1 and MAGE-A3, respectively, could distinguish HCC from liver cirrhosis with area under the curve (AUC) of 0.781 and 0.966, respectively (P ≤ 0.001). This evidence concerns the gene MAGEA3 and cirrhosis of liver.