In addition, they have been linked to tumor stemness and, therefore, may predict therapeutic response and prognosis.<h4>Aim of the study</h4>To investigate the expression pattern of MAGE-A1 and A3 genes in HCC patients and to evaluate their prognostic value.<h4>Subjects and methods</h4>This prospective four-year case-control study was conducted from 2020 to 2024 on 95 subjects classified into three groups. Here, MAGEA1 is linked to hepatocellular carcinoma.