Furthermore, these responses were linked to homocysteine (Hcy) level as another cardiovascular risk factor.<h4>Methods</h4>One hundred twenty-six obese newly diagnosed T2DM Egyptian patients (38.9% male and 61.1% female) fulfilling the inclusion criteria and signing the consent form were treated with Met plus Vilda for 12 months and genotyped for rs6741949 in the DPP4, rs6923761 in the GLP1R, and rs2285676 in the KATP (KCNJ11) genes. The gene discussed is KCNJ11; the disease is type 2 diabetes mellitus.