ORC1 and cerebral cavernous malformation: For instance, the Nogo-B receptor (NgBR), expressed on the surface of BECs, modulates the expression of cerebral cavernous malformation (CCM) genes, CCM1 and CCM2, through a HAT from the MYST family, known as histone acetyltransferase binding to ORC1 (HBO1; MYST2) [55].