PRDM16 and acute myeloid leukemia: Although PRDM16 isoforms were shown to differentially regulate normal and leukemic hematopoiesis, with especially the short isoform contributing to hematopoietic stem cells transformation and induction of AML in murine models [19–22], we did not see a differential impact of PRDM16 isoforms on outcome under clinical conditions in our analysis.