We recently performed RNA sequencing in several molecularly well-defined AML subgroups [27] and saw a clear differentiation of low (e.g. CBF-leukemias, CEBPA-bZIP-Indel) and high PRDM16 expression (NUP98-NSD1; UBTF-TD). This evidence concerns the gene PRDM16 and acute myeloid leukemia.