SLC7A8 and irritable bowel syndrome: The expression of SLC7A8 was significantly decreased after the exposure of fibroblasts with serosal fluids from healthy subjects and IBS patients (HC-CON and IBS-CON) and those from fecal fiber fermentation supernatant (HC-FERFIB), though only the exposure with HC-FERCON exceeded the cut-off for biological relevance (below the 0.5-fold mark) (Fig. 3).