Deposited interactomes derived from HCT116 and HKe-3 colon cancer cell lines, as well as HEK293 cells include numerous proteins directly associated with the actin cytoskeleton in the datasets for SH3BGRL and SH3BGRL-2 (Supplementary Table 1)26–28. The gene discussed is SH3BGRL2; the disease is malignant colon neoplasm.