Deposited interactomes derived from HCT116 and HKe-3 colon cancer cell lines, as well as HEK293 cells include numerous proteins directly associated with the actin cytoskeleton in the datasets for SH3BGRL and SH3BGRL-2 (Supplementary Table 1)26–28. Here, SH3BGRL is linked to malignant colon neoplasm.