ALB and edema: While septic mice exhibited fulminant pulmonary edema, extravasation of Evans blue-bound albumin (from 0.9 ± 0.2 pulmo/plasma ratio to 2.8 ± 0.4, P < 0.05, n = 5-14 mice/group) as well as fluid accumulation in the pulmonary interstitium (from 6.4 ± 0.4 μm to 12.3 ± 0.3 μm of alveolar thickening, indicative of interstitial pulmonary edema, P < 0.001, n = 6 mice/group) was diminished with antibody application (to 0.9 ± 0.2 pulmo/plasma ratio, P < 0.01 and 6.3 ± 0.7 μm, P < 0.001, respectively, Fig. 4a–c).