For early-stage HCC, OPN and IGFBP3 had AUROCs of 0.63 (95% CI 0.52–0.73) and 0.63 (95% CI 0.52–0.73), respectively, versus 0.80 (95% CI 0.71–0.90) for AFP (p=0.01 for both). This evidence concerns the gene IGFBP3 and hepatocellular carcinoma.