For any-stage HCC, OPN, and IGFBP3 had AUROCs of 0.73 (95% CI 0.65–0.81) and 0.70 (95% CI 0.62–0.79), respectively, compared with 0.85 (95% CI 0.78–0.91) for AFP (p=0.02 and p=0.01, respectively). The gene discussed is IGFBP3; the disease is hepatocellular carcinoma.