Lipotoxic medium induced RIPK1 and RIPK3, though not MLKL (Figure 4E and Supplemental Figure S3H, http://links.lww.com/HC9/C235), in both genotypes—a pattern consistent with transcriptomic data from MASLD patients (Figure 4F).22 Here, RIPK1 is linked to metabolic dysfunction-associated steatotic liver disease.