Using baseline measurements from 6245 participants in NEO study (the Netherlands Epidemiology of Obesity), we performed adjusted linear regression analyses to estimate associations between 34 parameters of XLHDL (very large HDL), LHDL (large HDL), MHDL (medium HDL), and SHDL (small HDL) particles, as well as ApoA1 (apolipoprotein A1), quantified using a high-throughput 1H-nuclear magnetic resonance metabolomics platform, and coagulation parameters. This evidence concerns the gene APOA1 and obesity disorder.