We particularly appreciate the identification of urinary MCP-1 as a standalone top performer in both DKD diagnosis (AUC = 0.722) and prediction, and the four-biomarker panel (GDF15, MCP-1, ANGPTL4, FGF23) achieving an impressive AUC of 0.873 for 2-year DKD risk. The gene discussed is ANGPTL4; the disease is diabetic kidney disease.