Although mean eIF4a3 levels were not different by either SELENOP genotypes (Supplemental Table 1), multiple regression modeling for tumor eIF4a3 levels revealed that expressing the SELENOPrs7579 genotype significantly modified the association between ER status and tumor eIF4a3 levels (Table 2, 2 degrees of freedom interaction p-value = 0.024). The gene discussed is ESR1; the disease is neoplasm.