The NER factor excision-repair cross-complementation group 5 (ERCC 5)/xeroderma pigmentosum complementation group G (XPG) is a 3 ́endonuclease that helps to excise the UV-damaged DNA strand and stabilizes the NER DNA-repair and basal transcription factor, transcription factor II H (TFIIH) (Pal et al. 2022). Here, ERCC2 is linked to xeroderma pigmentosum.